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VA/DoD Clinical Practice Guidelines

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Management of Major Depressive Disorder (MDD) (2009)

Update of CPG in Progress

FDA Warning/Regulatory Alert

FDA Warning/Regulatory Alert
This guideline references a drug(s) for which important revised regulatory and/or warning information has been released since completion of the CPG.

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Image of Major Depressive Disorder GuidelineThe guideline describes the critical decision points in the management of Major Depressive Disorder (MDD) and provides clear and comprehensive evidence based recommendations incorporating current information and practices for practitioners throughout the DoD and VA Health Care systems. The guideline is intended to improve patient outcomes and local management of patients with MDD.

Disclaimer:This Clinical Practice Guideline is intended for use only as a tool to assist a clinician/healthcare professional and should not be used to replace clinical judgment.

About the CPG Guideline Links Patient-Provider Tools Related Guidelines
The guideline is formatted as three algorithms, with annotations:
  • Algorithm 1
    - Primary Care - Initial Assessment and Diagnosis
  • Algorithm 2
    - Primary Care - Initial Treatment
  • Algorithm 3
    - Primary Care - Treatment Management and Follow-Up
Questions about the MDD Guideline
MDD Full Text (2009)
PDF: Please Read; Urgent MDD Full Text (2009) Errata
MDD Summary (2009)
PDF: Please Read; Urgent MDD Summary (2009) Errata
MDD Pocket Card (2009)
PDF: Please Read; Urgent MDD Pocket Card (2009) Errata
VA/DoD Essentials for Depression Screening and Assessment in Primary Care
VA/DoD Clinical Practice Guideline Provider Reference Cards: Depression
DEPRESSION: Fast Facts Brochure
DEPRESSION: What You Need to Know
Substance Use Disorder (SUD)
Bipolar Disorder in Adults (BD)