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VA/DoD Clinical Practice Guidelines

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Management of Major Depressive Disorder (MDD) (2022)

Image of the cover of the VA/DoD Clinical Practice Guideline Management of Major Depressive DisorderThe guideline describes the critical decision points in the management of Major Depressive Disorder (MDD) and provides clear and comprehensive evidence based recommendations incorporating current information and practices for practitioners throughout the DoD and VA Health Care systems. The guideline is intended to improve patient outcomes and local management of patients with MDD.

Disclaimer:This Clinical Practice Guideline is intended for use only as a tool to assist a clinician/healthcare professional and should not be used to replace clinical judgment.

About the CPG

The guideline is formatted as two algorithms with 36 evidence-based recommendations:

Module A: — Initial Assessment and Treatment
Module B: — Advanced Care Management

Questions about the MDD Guideline

Retired CPG's can be found on our archive page